Literaturnachweis - Detailanzeige
| Autor/inn/en | Mulder, Erik J.; Anderson, George M.; Kema, Ido P.; De Bildt, Annelies; Van Lang, Natasja D.J.; Den Boer, Johan A.; Minderaa Ruud B. |
|---|---|
| Titel | Platelet Serotonin Levels in Pervasive Developmental Disorders and Mental Retardation: Diagnostic Group Differences, Within-Group Distribution, and Behavioral Correlates. |
| Quelle | 43 (2004) 4, S.491 (9 Seiten)Infoseite zur Zeitschrift |
| Dokumenttyp | gedruckt; Zeitschriftenaufsatz |
| ISSN | 0890-8567 |
| Schlagwörter | Indo European Languages; Psychiatry; Young Adults; Mental Retardation; Autism |
| Abstract | Objective: To investigate group differences, the within-group distributions, and the clinical correlates of platelet serotonin (5-HT) levels in pervasive developmental disorders (PDD). Method: Platelet 5-HT levels were measured in Dutch children and young adults, recruited from 2001 through 2003, with PDD (autism, Asperger's and PDD-not otherwise specified [PDD-NOS]; n = 81) or with mental retardation (MR; n = 54) but without PDD, and in normal controls (n = 60). The distribution of platelet 5-HT levels was assessed using mixture-modeling analyses. Relationships between platelet 5-HT levels and a full range of demographic, clinical, and behavioral variables were examined. Results: Group mean ([+ or -] SD) platelet 5-HT levels (nmol/1[0.sup.9] platelets) were significantly higher in the autistic (4.51 [+ or -] 1.61, n = 33) and PDD-NOS (4.90 [+ or -] 1.54, n = 43) groups compared to the MR (3.48 [+ or -] 1.33, n = 54) or the normal control (3.58 [+ or -] 1.08, n = 60) groups ([F.sub.4,190] = 9.35, p < .001). Platelet 5-HT values in the combined PDD group showed a bimodal distribution, and an empirical cutpoint for hyperserotonemia was determined. None of the behavioral variables examined was significantly associated with platelet 5-HT levels. Conclusions: The platelet hyperserotonemia of autism was replicated in Dutch subjects. Platelet 5-HT levels were also increased in PDD-NOS, while no elevation was seen in MR. Platelet 5-HT levels appeared to be bimodally distributed in the PDD group, with an apparent hyperserotonemic subgroup. J. Am. Acad. Child Adolesc. Psychiatry, 2004;43(4):491-499. Key Words: platelet serotonin, autism, pervasive developmental disorder-not otherwise specified, mental retardation, pervasive developmental disorders, hyperserotonemia, mixture-modeling. (Author). |
| Anmerkungen | Lippincott Williams & Wilkins, P.O. Box 1620, Hagerstown, MD 21741. Tel: 800-638-3030 (Toll Free); Fax: 301-223-2400. |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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